The Global Security News: 1. US Security from Michael_Novakhov (88 sites): Eurasia Review: Uncovered A Trove Of Genes That Could Hold Key To How Humans Evolved

Researchers at the Donnelly Centre in Toronto have found that dozens
of genes, previously thought to have similar roles across different
organisms, are in fact unique to humans and could help explain how our
species came to exist.

These genes code for a class of proteins known as transcription
factors, or TFs, which control gene activity. TFs recognize specific
snippets of the DNA code called motifs, and use them as landing sites to
bind the DNA and turn genes on or off.

Previous research had suggested that TFs which look similar across
different organisms also bind similar motifs, even in species as diverse
as fruit flies and humans. But a new study from Professor Timothy Hughes‘ lab, at the Donnelly Centre for Cellular and Biomolecular Research, shows that this is not always the case.

Writing in the journal Nature Genetics, the researchers
describe a new computational method which allowed them to more
accurately predict motif sequences each TF binds in many different
species. The findings reveal that some sub-classes of TFs are much more
functionally diverse than previously thought.

“Even between closely related species there’s a non-negligible
portion of TFs that are likely to bind new sequences,” says Sam Lambert,
former graduate student in Hughes’ lab who did most of the work on the
paper and has since moved to the University of Cambridge for a
postdoctoral stint.

“This means they are likely to have novel functions by regulating
different genes, which may be important for species differences,” he
says.

Even between chimps and humans, whose genomes are 99 per cent
identical, there are dozens of TFs which recognize diverse motifs
between the two species in a way that would affect expression of
hundreds of different genes.

“We think these molecular differences could be driving some of the
differences between chimps and humans,” says Lambert, who won the
Jennifer Dorrington Graduate Research Award for outstanding doctoral
research at U of T’s Faculty of Medicine.

To reanalyze motif sequences, Lambert developed new software which
looks for structural similarities between the TFs’ DNA binding regions
that relate to their ability to bind the same or different DNA motifs.
If two TFs, from different species, have a similar composition of
amino-acids, building blocks of proteins, they probably bind similar
motifs. But unlike older methods, which compare these regions as a
whole, Lambert’s automatically assigns greater value to those
amino-acids– a fraction of the entire region– which directly contact
the DNA. In this case, two TFs may look similar overall, but if they
differ in the position of these key amino-acids, they are more likely to
bind different motifs. When Lambert compared all TFs across different
species and matched to all available motif sequence data, he found that
many human TFs recognize different sequences–and therefore regulate
different genes– than versions of the same proteins in other animals.

The finding contradicts earlier research, which stated that almost
all of human and fruit fly TFs bind the same motif sequences, and is a
call for caution to scientists hoping to draw insights about human TFs
by only studying their counterparts in simpler organisms.

“There is this idea that has persevered, which is that the TFs bind
almost identical motifs between humans and fruit flies,” says Hughes,
who is also a professor in U of T’s Department of Molecular Genetics and
Fellow of the Canadian Institute for Advanced Research. “And while
there are many examples where these proteins are functionally conserved,
this is by no means to the extent that has been accepted.”

As for TFs that have unique human roles, these belong to the rapidly
evolving class of so-called C2H2 zinc finger TFs, named for zinc
ion-containing finger-like protrusions, with which they bind the DNA.

Their role remains an open question but it is known that organisms
with more diverse TFs also have more cell types, which can come together
in novel ways to build more complicated bodies.

Hughes is excited about a tantalizing possibility that some of these
zinc finger TFs could be responsible for the unique features of human
physiology and anatomy–our immune system and the brain, which are the
most complex among animals. Another concerns sexual dimorphism:
countless visible, and often less obvious, differences between sexes
that guide mate selection–decisions that have an immediate impact on
reproductive success, and can also have profound impact on physiology in
the long term. The peacock’s tail or facial hair in men are classic
examples of such features.

“Almost nobody in human genetics studies the molecular basis of
sexual dimorphism, yet these are features that all human beings see in
each other and that we are all fascinated with,” says Hughes. “I’m
tempted to spend the last half of my career working on this, if I can
figure out how to do it!”

Eurasia Review

1. US Security from Michael_Novakhov (88 sites)

The Global Security News

Blogs from Michael_Novakhov (21 sites): The FBI News Review: Alerta de Google: fbi counterintelligence: New Comey op-ed: The “deep state treason” conspiracy theory about Russiagate is the dumbest of …

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May 28, 2019
Alerta de Google: fbi counterintelligence: New Comey op-ed: The “deep state treason” conspiracy theory about Russiagate is the dumbest of …
“fbi scandal” – Google News: 2019 NBA Draft Early Entry List: Who declared? Who is returning? Who are we waiting on? – NBCSports.com
“mueller” – Google News: Why Mueller needs to get in the hot seat – CNN
Alerta de Google: fbi: James Comey calls Clinton ‘dirt’ tipster Joseph Mifsud a ‘Russian agent’
Alerta de Google: fbi: Scott Brunner Named Special Agent in Charge of the San Diego Field Office

Alerta de Google: fbi counterintelligence: New Comey op-ed: The “deep state treason” conspiracy theory about Russiagate is the dumbest of …

FBI from Michael_Novakhov (28 sites)
“When those investigations are over,” he writes in his new WaPo piece about the DOJ’s multiple probes into the origins of Russiagate, “they will find the work was done appropriately and focused only on discerning the truth of very serious allegations.” If that’s a bet then I’ll take that action.
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“fbi scandal” – Google News: 2019 NBA Draft Early Entry List: Who declared? Who is returning? Who are we waiting on? – NBCSports.com

FBI from Michael_Novakhov (28 sites)
LSU will still have a talented roster available for next season despite six players declaring early for the 2019 NBA Draft process earlier this offseason. Point guard Tremont Waters and big man Naz Reid are both staying in the draft.
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“mueller” – Google News: Why Mueller needs to get in the hot seat – CNN

FBI from Michael_Novakhov (28 sites)
New reporting suggests that Mueller’s team does not want him to testify publicly before Congress about his probe into Russian interference and allegations of obstruction of justice by President Trump.
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Alerta de Google: fbi: James Comey calls Clinton ‘dirt’ tipster Joseph Mifsud a ‘Russian agent’

FBI from Michael_Novakhov (28 sites)
Former FBI Director James Comey made a bold assertion about the Hillary Clinton “dirt” tipster’s ties to Russia that goes further than what special … Alerta de Google: fbi
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Alerta de Google: fbi: Scott Brunner Named Special Agent in Charge of the San Diego Field Office

FBI from Michael_Novakhov (28 sites)
FBI Director Christopher Wray has named Scott Brunner as the special agent in charge of the San Diego Field Office. Mr. Brunner started his FBI career as a special agent in 1995. He was first assigned to the Portland Field Office in Oregon, where he primarily investigated violent and organized crime.
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Blogs from Michael_Novakhov (21 sites)

1. New York and Brooklyn from Michael_Novakhov (111 sites): “Brooklyn Academy of Music” – Google News: João Laia Named Chief Curator at Kiasma Museum of Contemporary Art – Artforum

João Laia Named Chief Curator at Kiasma Museum of Contemporary Art  Artforum

The Kiasma Museum of Contemporary Art in Helsinki has appointed Portugal-based curator João Laia as its new chief curator of exhibitions. Once he takes up …

“Brooklyn Academy of Music” – Google News

1. New York and Brooklyn from Michael_Novakhov (111 sites)

The Brooklyn News: 1. New York and Brooklyn from Michael_Novakhov (111 sites): “Brooklyn Academy of Music” – Google News: João Laia Named Chief Curator at Kiasma Museum of Contemporary Art – Artforum

João Laia Named Chief Curator at Kiasma Museum of Contemporary Art  Artforum

The Kiasma Museum of Contemporary Art in Helsinki has appointed Portugal-based curator João Laia as its new chief curator of exhibitions. Once he takes up …

“Brooklyn Academy of Music” – Google News

1. New York and Brooklyn from Michael_Novakhov (111 sites)

The Brooklyn News

The Brooklyn Bridge: 1. New York and Brooklyn from Michael_Novakhov (111 sites): “Brooklyn Academy of Music” – Google News: João Laia Named Chief Curator at Kiasma Museum of Contemporary Art – Artforum

João Laia Named Chief Curator at Kiasma Museum of Contemporary Art  Artforum

The Kiasma Museum of Contemporary Art in Helsinki has appointed Portugal-based curator João Laia as its new chief curator of exhibitions. Once he takes up …

“Brooklyn Academy of Music” – Google News

1. New York and Brooklyn from Michael_Novakhov (111 sites)

The Brooklyn Bridge

Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: RT @HuffPostPol: John Bolton has been dubbed a “war monger” and “human defect” by North Korea after he condemned the country’s recent missi…

John Bolton has been dubbed a “war monger” and “human defect” by North Korea after he condemned the country’s recent missile tests. huffp.st/Rd2oWcR


Posted by

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on Monday, May 27th, 2019 7:03pm
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on Tuesday, May 28th, 2019 10:30pm

23 likes, 18 retweets

mikenov on Twitter

Michael Novakhov on Twitter from Michael_Novakhov (3 sites)

Blogs from Michael_Novakhov (21 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: RT @HuffPostPol: John Bolton has been dubbed a “war monger” and “human defect” by North Korea after he condemned the country’s recent missi…

John Bolton has been dubbed a “war monger” and “human defect” by North Korea after he condemned the country’s recent missile tests. huffp.st/Rd2oWcR


Posted by

HuffPostPol
on Monday, May 27th, 2019 7:03pm
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mikenov
on Tuesday, May 28th, 2019 10:30pm

23 likes, 18 retweets

mikenov on Twitter

Michael Novakhov on Twitter from Michael_Novakhov (3 sites)

Blogs from Michael_Novakhov (21 sites)

1. New York and Brooklyn from Michael_Novakhov (111 sites): “Brooklyn Music” – Google News: A Legendary Hip-Hop Archive Finds a Home in Harlem – Atlas Obscura

A Legendary Hip-Hop Archive Finds a Home in Harlem  Atlas Obscura

In the 1970s and 1980s, New York City was the epicenter of hip-hop music and culture. Fred “Fab 5 Freddy” Brathwaite, Brooklyn-born director, visual artist, and …

“Brooklyn Music” – Google News

1. New York and Brooklyn from Michael_Novakhov (111 sites)

1. New York and Brooklyn from Michael_Novakhov (111 sites): News 12 – Home: American Red Cross recommends swim lessons as summer season approaches

Memorial Day Weekend marks the opening of New York City beaches and with the warm weather swimmers are sure to be out in the waters taking a dip. News 12 spoke with swim instructors about safety tips ahead of beach and pool season.

News 12 – Home

1. New York and Brooklyn from Michael_Novakhov (111 sites)

The Global Security News: “fbi surveillance” – Google News: Democrats don’t want to investigate the investigators? They must have something to hide – Washington Examiner

Feedly Logo
May 28, 2019
“fbi surveillance” – Google News: Democrats don’t want to investigate the investigators? They must have something to hide – Washington Examiner
“Peter Strzok” – Google News: James Comey: No ‘treason.’ No coup. Just lies — and dumb lies at that. – The Washington Post
Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…
Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:15 PM 5/28/2019 Trump News Review – Saved Stories trumpandtrumpism.com/2019/05/28/515…

“fbi surveillance” – Google News: Democrats don’t want to investigate the investigators? They must have something to hide – Washington Examiner

FBI from Michael_Novakhov (28 sites)
Democrats don’t want to investigate the investigators? They must have something to hide Washington ExaminerUsing the logic of Democrats and the media from the last two years, the only conclusion to be reached from their hysteria over Attorney General William Barr is …
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“Peter Strzok” – Google News: James Comey: No ‘treason.’ No coup. Just lies — and dumb lies at that. – The Washington Post

FBI from Michael_Novakhov (28 sites)
James Comey is a former director of the FBI and a former deputy attorney general. It is tempting for normal people to ignore our president when he starts ranting about treason and corruption at the FBI.
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Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…

FBI from Michael_Novakhov (28 sites)
5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521… Posted by mikenov on Tuesday, May 28th, 2019 9:23pm mikenov on Twitter
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Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:15 PM 5/28/2019 Trump News Review – Saved Stories trumpandtrumpism.com/2019/05/28/515…

FBI from Michael_Novakhov (28 sites)
5:15 PM 5/28/2019 Trump News Review – Saved Stories trumpandtrumpism.com/2019/05/28/515… Posted by mikenov on Tuesday, May 28th, 2019 9:18pm mikenov on Twitter Michael Novakhov on Twitter from Michael_Novakhov (3 sites)
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The Global Security News

Blogs from Michael_Novakhov (21 sites): The FBI News Review: “fbi surveillance” – Google News: Democrats don’t want to investigate the investigators? They must have something to hide – Washington Examiner

Feedly Logo
May 28, 2019
“fbi surveillance” – Google News: Democrats don’t want to investigate the investigators? They must have something to hide – Washington Examiner
“Peter Strzok” – Google News: James Comey: No ‘treason.’ No coup. Just lies — and dumb lies at that. – The Washington Post
Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…
Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:15 PM 5/28/2019 Trump News Review – Saved Stories trumpandtrumpism.com/2019/05/28/515…

“fbi surveillance” – Google News: Democrats don’t want to investigate the investigators? They must have something to hide – Washington Examiner

FBI from Michael_Novakhov (28 sites)
Democrats don’t want to investigate the investigators? They must have something to hide Washington ExaminerUsing the logic of Democrats and the media from the last two years, the only conclusion to be reached from their hysteria over Attorney General William Barr is …
Read More

“Peter Strzok” – Google News: James Comey: No ‘treason.’ No coup. Just lies — and dumb lies at that. – The Washington Post

FBI from Michael_Novakhov (28 sites)
James Comey is a former director of the FBI and a former deputy attorney general. It is tempting for normal people to ignore our president when he starts ranting about treason and corruption at the FBI.
Read More

Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…

FBI from Michael_Novakhov (28 sites)
5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521… Posted by mikenov on Tuesday, May 28th, 2019 9:23pm mikenov on Twitter
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Crime and Criminology from Michael_Novakhov (10 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:15 PM 5/28/2019 Trump News Review – Saved Stories trumpandtrumpism.com/2019/05/28/515…

FBI from Michael_Novakhov (28 sites)
5:15 PM 5/28/2019 Trump News Review – Saved Stories trumpandtrumpism.com/2019/05/28/515… Posted by mikenov on Tuesday, May 28th, 2019 9:18pm mikenov on Twitter Michael Novakhov on Twitter from Michael_Novakhov (3 sites)
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The FBI News Review

Blogs from Michael_Novakhov (21 sites)

The Global Security News: 1. World from Michael_Novakhov (25 sites): Reuters: World News: No signs Brazil prison killings will spread: presidential spokesman

There are no signs that a spate of deadly prison violence in the northern Brazilian city of Manaus will spread to other parts of the country, the presidential spokesman said on Tuesday.

Reuters: World News

1. World from Michael_Novakhov (25 sites)

The Global Security News

Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…

5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…


Posted by

mikenov
on Tuesday, May 28th, 2019 9:23pm

mikenov on Twitter

Michael Novakhov on Twitter from Michael_Novakhov (3 sites)

Blogs from Michael_Novakhov (21 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): mikenov on Twitter: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…

5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts trumpandtrumpism.com/2019/05/28/521…


Posted by

mikenov
on Tuesday, May 28th, 2019 9:23pm

mikenov on Twitter

Michael Novakhov on Twitter from Michael_Novakhov (3 sites)

Blogs from Michael_Novakhov (21 sites)

Michael Novakhov on Twitter from Michael_Novakhov (3 sites): Twitter search feed for: michael novakhov.: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts https://trumpandtrumpism.com/2019/05/28/521-pm-5-28-2019-michael-novakhov-sharednewslinks%e2%84%a0-in-50-brief-posts/ …

5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts https://trumpandtrumpism.com/2019/05/28/521-pm-5-28-2019-michael-novakhov-sharednewslinks%e2%84%a0-in-50-brief-posts/ …

Twitter search feed for: michael novakhov.

Michael Novakhov on Twitter from Michael_Novakhov (3 sites)

Blogs from Michael_Novakhov (21 sites): Michael Novakhov on Twitter from Michael_Novakhov (3 sites): Twitter search feed for: michael novakhov.: 5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts https://trumpandtrumpism.com/2019/05/28/521-pm-5-28-2019-michael-novakhov-sharednewslinks%e2%84%a0-in-50-brief-posts/ …

5:21 PM 5/28/2019 Michael Novakhov – SharedNewsLinks℠ – In 50 Brief Posts https://trumpandtrumpism.com/2019/05/28/521-pm-5-28-2019-michael-novakhov-sharednewslinks%e2%84%a0-in-50-brief-posts/ …

Twitter search feed for: michael novakhov.

Michael Novakhov on Twitter from Michael_Novakhov (3 sites)

Blogs from Michael_Novakhov (21 sites)

1. New York and Brooklyn from Michael_Novakhov (111 sites): Brooklyn Based: The Coney Island roller coasters you have to brave

Photo: Kara Zuaro

It doesn’t really feel like summer until you’re swinging over the boardwalk, feeling the sand in your shoes and the wind in your hair. Luna Park, has around 25 rides, including the kid-friendly swings pictured above. Of course you’ll need to ride the Cyclone, a land-marked wooden roller coaster built in 1927, known for is its rickety roar, clicking and clacking like it could fall apart at any moment during its tight turns and steep drops. But if you prefer a more modern coaster with a bigger adrenaline rush, the 115-foot vertical lift of the Thunderbolt is even more terrifying than the vertical drop that follows it. Luna Park offers single-ride tickets and day passes, but you’ll need to pay separately to ride Coney Island’s iconic Ferris wheel, which is part of Deno’s Wonder Wheel, an adjacent park with a wider array of kiddie rides. Luna Park is located at 1000 Surf Avenue, and Deno’s Wonder Wheel is located right next-door at 3059 Denos D. Vourderis Place. 

Brooklyn Based

1. New York and Brooklyn from Michael_Novakhov (111 sites)

1. New York and Brooklyn from Michael_Novakhov (111 sites): “brooklyn crime news” – Google News: Business-Loan Kingpin Sentenced to 10 Years for Smuggling Weed – Washington Post

Business-Loan Kingpin Sentenced to 10 Years for Smuggling Weed  Washington Post

Jonathan Braun, a marijuana trafficker who built a predatory lending company while free on bail, was sentenced to 10 years in prison on drug-smuggling …

“brooklyn crime news” – Google News

1. New York and Brooklyn from Michael_Novakhov (111 sites)

1. New York and Brooklyn from Michael_Novakhov (111 sites): Brooklyn Based: Summer in a glass: Bad Seed’s small-batch cider

Hard cider has a reputation for being an autumnal drink, but a not-too-sweet, fruit-forward cider can taste like summer in a glass. Bad Seed Cider cans and distributes their flagship Dry Hard Cider, but to sample all their small-batch specialties, including Hibiscus Ginger Cider, Honey Mint Cider, and Space Cadet (hopped with Galaxy and Apollo hops), you’ve got to hit one of their upstate tap rooms or visit them in Crown Heights, where they keep 12 ciders on draft. They also have 8 rotating taps of New York craft beers and a cozy little backyard, and they’re happy to fill growlers to-go. Bad Seed Taproom, 585 Franklin Avenue, Brooklyn, NY; (718) 975-0690. Photo: Bad Seed Cider.

Related:
6 Ciders to fall for
The cider craze keeps growing

Brooklyn Based

1. New York and Brooklyn from Michael_Novakhov (111 sites)

1. New York and Brooklyn from Michael_Novakhov (111 sites): “Borough Park Brooklyn” – Google News: OPINION: Walt Whitman, black Brooklyn, Wounded Knee and me – Brooklyn Daily Eagle

OPINION: Walt Whitman, black Brooklyn, Wounded Knee and me  Brooklyn Daily Eagle

What does the literary icon Walt Whitman mean to black Brooklyn?

“Borough Park Brooklyn” – Google News

1. New York and Brooklyn from Michael_Novakhov (111 sites)